我所郏东耀老师课题组完成的论文《MRT-HER2Net: topology-aware multi-resolution convolutional neural networks for biomarker scoring of HER2 in breast cancer》于2025-11在《Physics in Medicine and Biology》正式发表。论文摘要如下：
Abstract: Abstract Immunohistochemistry is a cornerstone of breast cancer diagnosis, particularly for assessing human epidermal growth factor receptor 2 (HER2), which guides patient classification and targeted therapy. However, manual scoring in clinical practice is labor-intensive and prone to variability from subjective interpretation. Existing automated methods rely on single-resolution images, deviating from multi-scale diagnostic practices and limiting the integration of local details with global patterns. They also overlook spatial topological relationships, such as connectivity and distribution of stained regions, leading to misinterpretation of HER2 expression and reduced diagnostic accuracy and interpretability. We propose multi-resolution and topological HER2 scoring network (MRT-HER2Net), an innovative deep learning framework for automatic HER2 scoring. The network adopts a unique dual-branch design consisting of a fine-grained branch and a topological branch, which process concentric multi-resolution images to extract local details and global topological features, respectively. These features are deeply fused through skip connections and trained end-to-end using a joint loss function. Through the proposed PersistMap block, topological modeling is introduced into HER2 scoring for the first time, addressing the challenges of samples with complex HER2 staining and distribution patterns. MRT-HER2Net achieved high accuracy (Macro F1: 0.912) and consistency (MCC: 0.899, PCC: 0.928) on a clinical dataset of 8,006 image slices. It outperforms existing methods in accuracy, consistency, and interpretability, paving the way for quantitative pathology research based on spatial modeling.
引用信息：Zihao He, Dongyao Jia, Ziqi Li, Feng Zeng, Liang Liu. MRT-HER2Net: topology-aware multi-resolution convolutional neural networks for biomarker scoring of HER2 in breast cancer. Physics in Medicine and Biology, 2025-11-05. DOI: 10.1088/1361-6560/ae1788